{"id":1156,"date":"2025-08-18T09:18:36","date_gmt":"2025-08-18T09:18:36","guid":{"rendered":"https:\/\/slcelitemedicalcare.com\/?page_id=1156"},"modified":"2025-08-18T14:05:04","modified_gmt":"2025-08-18T14:05:04","slug":"targeted-therapy","status":"publish","type":"page","link":"https:\/\/slcelitemedicalcare.com\/id\/targeted-therapy\/","title":{"rendered":"Terapi Bertarget"},"content":{"rendered":"
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Terapi Bertarget<\/h2>\t\t\t\t<\/div>\n\t\t\t\t
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  • \n\t\t\t\t\t\t\t\t\t\tRumah<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
  • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/path><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tTerapi Bertarget<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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    Targeted Therapy: Precision Cancer Treatment<\/h2>\t\t\t\t<\/div>\n\t\t\t\t
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    Terapi target<\/b>\u00a0is a type of cancer treatment that uses drugs or other substances to\u00a0<\/span>identify and attack specific molecules<\/b>\u00a0(like proteins or genes) involved in cancer cell growth and survival. Unlike chemotherapy, which affects all rapidly dividing cells, targeted therapy selectively disrupts cancer cells while minimizing damage to healthy tissues.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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    Cara Kerjanya<\/b><\/p>

    Targeted therapies interfere with specific\u00a0biological pathways\u00a0that allow cancer cells to grow, divide, and spread. Key mechanisms include:<\/span><\/p>

    1. Blocking Growth Signals<\/b><\/li><\/ol>

      Tyrosine Kinase Inhibitors (TKIs)\u00a0(e.g., Imatinib, Erlotinib) \u2013 Inhibit enzymes that promote cancer cell proliferation.<\/span><\/p>

      Monoclonal Antibodies\u00a0(e.g., Trastuzumab, Cetuximab) \u2013 Bind to receptors on cancer cells, preventing growth signals.<\/span><\/p>

      1. Preventing Angiogenesis (Blood Vessel Formation)<\/b><\/li><\/ol>

        VEGF Inhibitors\u00a0(e.g., Bevacizumab) \u2013 Stop tumors from forming new blood vessels, starving them of nutrients.<\/span><\/p>

        1. Promoting Apoptosis (Programmed Cell Death)<\/b><\/li><\/ol>

          BCL-2 Inhibitors\u00a0(e.g., Venetoclax) \u2013 Force cancer cells to self-destruct.<\/span><\/p>

          1. Disrupting DNA Repair<\/b><\/li><\/ol>

            PARP Inhibitors\u00a0(e.g., Olaparib) \u2013 Prevent cancer cells from fixing DNA damage, leading to cell death.<\/span><\/p>

            1. Immune System Modulation<\/b><\/li><\/ol>

              Checkpoint Inhibitors\u00a0(e.g., Pembrolizumab) \u2013 Help the immune system recognize and attack cancer cells.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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              Kondisi yang Diobati:<\/b><\/p>

              Targeted therapy is used for\u00a0<\/span>specific cancers with identifiable molecular markers<\/b>, including:<\/span><\/p>

              1. Kanker payudara<\/b>\u00a0\u2013\u00a0*HER2-positive*\u00a0(Trastuzumab),\u00a0<\/span>HR-positive<\/span><\/i>\u00a0(CDK4\/6 inhibitors like Palbociclib).<\/span><\/li>
              2. Kanker Paru-paru<\/b>\u00a0\u2013\u00a0<\/span>EGFR mutations<\/span><\/i>\u00a0(Osimertinib),\u00a0<\/span>ALK rearrangements<\/span><\/i>\u00a0(Crizotinib).<\/span><\/li>
              3. Leukemia\/Lymphoma<\/b>\u00a0\u2013\u00a0<\/span>BCR-ABL fusion<\/span><\/i>\u00a0(Imatinib for CML),\u00a0<\/span>BTK inhibitors<\/span><\/i>\u00a0(Ibrutinib for CLL).<\/span><\/li>
              4. Colorectal Cancer<\/b>\u00a0\u2013\u00a0<\/span>KRAS wild-type<\/span><\/i>\u00a0(Cetuximab).<\/span><\/li>
              5. Melanoma<\/b>\u00a0\u2013\u00a0<\/span>BRAF V600E mutation<\/span><\/i>\u00a0(Dabrafenib + Trametinib).<\/span><\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t
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                Advantages Over Traditional Chemotherapy<\/b><\/p>

                Feature<\/b><\/p><\/th>

                Terapi Bertarget<\/b><\/p><\/th>

                Kemoterapi<\/b><\/p><\/th><\/tr><\/thead>

                Specificity<\/span><\/p><\/td>

                Attacks cancer-specific molecules<\/span><\/p><\/td>

                Affects all fast-dividing cells<\/span><\/p><\/td><\/tr>

                Side Effects<\/span><\/p><\/td>

                Fewer (e.g., rash, fatigue)<\/span><\/p><\/td>

                Severe (nausea, hair loss)<\/span><\/p><\/td><\/tr>

                Resistance Risk<\/span><\/p><\/td>

                Develops over time<\/span><\/p><\/td>

                Common<\/span><\/p><\/td><\/tr>

                Administration<\/span><\/p><\/td>

                Often oral (pills)<\/span><\/p><\/td>

                Mostly IV infusions<\/span><\/p><\/td><\/tr>

                Personalization<\/span><\/p><\/td>

                Requires biomarker testing<\/span><\/p><\/td>

                Broadly used<\/span><\/p><\/td><\/tr><\/tbody><\/table>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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                Key Benefits<\/b><\/p>

                • Higher precision<\/b>\u00a0\u2013 Less harm to normal cells.<\/span>
                  <\/span><\/li>
                • Better tolerated<\/b>\u00a0\u2013 Reduced severe side effects.<\/span>
                  <\/span><\/li>
                • Improved outcomes<\/b>\u00a0\u2013 Prolongs survival in certain cancers (e.g., CML, HER2+ breast cancer).<\/span><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"

                  Home Targeted Therapy Targeted Therapy: Precision Cancer Treatment Targeted therapy\u00a0is a type of cancer treatment that uses drugs or other substances to\u00a0identify and attack specific molecules\u00a0(like proteins or genes) involved in cancer cell growth and survival. Unlike chemotherapy, which affects all rapidly dividing cells, targeted therapy selectively disrupts cancer cells while minimizing damage to healthy […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"footnotes":""},"class_list":["post-1156","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/slcelitemedicalcare.com\/id\/wp-json\/wp\/v2\/pages\/1156","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/slcelitemedicalcare.com\/id\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/slcelitemedicalcare.com\/id\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/slcelitemedicalcare.com\/id\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/slcelitemedicalcare.com\/id\/wp-json\/wp\/v2\/comments?post=1156"}],"version-history":[{"count":0,"href":"https:\/\/slcelitemedicalcare.com\/id\/wp-json\/wp\/v2\/pages\/1156\/revisions"}],"wp:attachment":[{"href":"https:\/\/slcelitemedicalcare.com\/id\/wp-json\/wp\/v2\/media?parent=1156"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}